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Therefore, overexpression of MTs with serum zinc deficiency together with ceruloplasmin deficiency could lead to a deficiency in T-lymphocyte response

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Studies have found that the Tc9 subset (IL-9-secreting CD8 + T cells) reduces its own lipid peroxidation and ferroptosis by enhancing fatty acid oxidation via the IL-9/STAT3 signaling axis, allowing it to survive longer in the TME and exhibit stronger anti-tumor capabilities (143)

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