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This reaction, termed glutathione conjugation, substantially alters the physicochemical properties of the substrate, typically converting it from a predominantly lipophilic, membrane-permeable compound into a more hydrophilic, water-soluble derivative

A previous study identified a vitamin D response element in the promoter region of the insulin receptor gene, suggesting that vitamin D plays a role in the transcriptional regulation of insulin (58)

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Some patients have experienced mild swelling or redness at the injection site, upset stomach, or lightheadedness