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TB-500 complements these findings with data suggesting effects on myogenesis, muscle fiber regeneration, and wound repair, particularly through its role in actin regulation and vascular endothelial growth factor (VEGF) expression

A single nutritional intervention strategy may be limited

The Xkr8 2DA (p.D351A&D354A) KI mice were generated via CRISPRCas9-mediated KI of the 2DA mutant cassette into exon 3 of Xkr8 gene (see Supplementary Fig