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10.4103/cmi.cmi_150_23 Current Medical Issues

The p53 involvement in apoptosis is largely depends on its transcriptional upregulation of Bax protein, which disrupts mitochondrial membrane integrity, and pro-apoptotic factors PUMA and NOXA, which promote Bax and Bak activity, releasing them from complexes with anti-apoptotic members of the Bcl-2 family (36)

Some children with ASD are reported to have a spectrum of mitochondrial dysfunction of differing severity (3)

Consuming foods grown in poor quality soil Even in food sources, the amount of selenium is largely dependent on soil conditions that the food grew in therefore even within the same food, levels of selenium can vary widely, and selenium benefits may be found in crops grown in certain locations more so than others