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While the ceiling culture technique was developed to circumvent this, it often induces a morphological shift from unilocular to multilocular phenotypes and presents a risk of dedifferentiation of the mature adipocytes as well ( 3.2 2D models of lipedema Many 2D in vitro models of lipedema have utilized adipose-derived stem cells (ASCs) isolated from patient samples ( expression in lipedema-differentiated adipocytes compared to healthy-differentiated adipocytes ( Since lipedema involves significant vascular changes, researchers have increasingly incorporated endothelial cells into their disease models

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SNAT1 (Sodium-coupled neutral amino acid transporter 1): This transporter is involved in the sodium-dependent uptake of glutamine and other neutral amino acids