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The studies include one conducted under the auspices of the National Institute on Aging, one of the National Institutes of Health, published in the peer-reviewed journal Aging Cell in 2016

The research literature consistently describes DSIP as a sleep-promoting neuromodulator not a hypnotic or sedative agent with a modulating effect on sleep and wake functions that is most pronounced when sleep is disturbed, and minimal in healthy subjects without sleep disruption

Veterinary World 15 (9), 23572364

D57 (CTR) and D254 (G), were predicted protonated, however, visual inspection did not support this prediction because of their solvent-exposed location and, therefore, were modelled in the anionic side chain form