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Adv Pharmacol 85:195219 Gunawan BK et al (2006) c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity

Thereby, the magnitude and duration of TGF- signaling is carefully controlled at many different levels, including the synthesis and activation of latent TGF- isoforms, receptor activation and stability, and the activation and stability of intracellular Smad molecules and other downstream signaling molecules