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Grand ambitions but little concrete progress Three years on from the initial proposal, cracks are beginning to show, possibly due to the sheer ambition of the project

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Future investigations in this area should examine the underlying pathways, such as mitochondrial alterations [122]

The role of 3-AR and the impact of gene polymorphism Additionally, 3-AR also plays a role in lipid metabolism, indicating that adrenergic receptor activation is important in the development of MASLD