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Interleukin 21 Drives a Hypermetabolic State and CD4(+) T-Cell-Associated Pathogenicity in Chronic Intestinal Inflammation

Ngu DM, Myti S, Khan AA, Keita J, Moore T, Andega P, et al

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In a 5xFAD, five familial AD-related mutations, AD mouse model, mice exhibited markers for lipid peroxidation and ferroptosis along with cognitive decline, which improved with the generation of transgenic 5xFAD mice that overexpress GPX4 [353], displaying the crucial role of GPX4 in the mediation of ferroptosis-induced neurodegeneration