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Modulation of CNS signal transduction pathways and gene expression by mood-stabilizing agents: therapeutic implications

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5 Carnitine, a compound biosynthesized in the liver and kidneys from the amino acids lysine or methionine, is required for the transport of long-chain fatty acids into the mitochondria and is important in energy metabolism

Since the process of osmoregulation, which guards the ocular surface epithelia and maintains normal vision, is affected when the osmolarity of the tears is greater than that of the epithelial cells, tear hyperosmolarity (THO) is considered an initial, important step in the development, progression, and aggravation of DED