parkinson glutathione The system in Parkinson's disease and its progression Ferroptosis-related factors in the substantia

The standard treatment, recombinant tissue-type plasminogen activator (rt-PA), is effective initially, but its efficacy declines rapidly over time as the risk of complications, such as hemorrhagic transformation and blood-brain barrier dysfunction, increases

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Early and late stages differ in BBB integrity, neurovascular dysfunction, neuroinflammatory status, and the expression or function of transport-related molecules such as LRP1 and RAGE, all of which may influence nanoparticle performance and delivery consistency (Petralla et al., 2024a)

E2 further upregulates key mitochondrial antioxidant enzymes, including SOD2, GPx and catalase, thereby enhancing ROS-scavenging capacity (109)