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Furthermore, the top 10 down regulated metabolites were Eicosapentaenoic acid, 1,4-Benzothiazine-O-quinonimine, Irilone de Iris, Hovenidulcioside B1, 2-Methyl-3-hydroxyphenylpropionic acid, Propionylcholine, cis-4- Hydroxycyclohexylacetic acid, N-Phenyl-1-naphthylamine, Coumarin, and 5,7,4-Trihydroxy-3-methoxyflavanone 4-O-isobutyrate metabolites (Figure 3B)

K., Sood, A., Hofmeyr, G

Patients with MASH exhibit increased Th2/Treg and Th17/Treg ratios in peripheral blood compared to healthy controls, and the hepatic Th17/Treg ratio is also elevated (135, 136)

Thus, a H 2 O 2 scavenging cycle requires fast oxidation of the peroxidase but also a fast reduction to restore its catalytic activity