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In: McManus LM, Mitchell RN (eds) Pathobiology of Human Disease

Therefore, there is a need for more specific treatments with fewer side effects

Bidirectional signaling further reinforces this crosstalk: tumor-cellderived lactate, HMGB1, prostaglandins, and oxidized lipids polarize macrophages toward either ferroptosis-promoting (M1-like) or ferroptosis-restraining (M2-like) states