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In other words, the specific ER-mediated downstream pathway inhibited by tamoxifen was reactivated by ferulic acid, indicating that ferulic acid affects ER activity

PetersenA-KKrumsiekJWgeleBTheisFJWichmannH-EGiegerCet al

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[] D 25 =30(c 2, H 2 O) [Value in reference: [] D 25 =31] 1 H-NMR(D 2 O, ppm): 2.3(m, 2H, CH 2 CO 2 H), 3.1(s, 9H, (CH 3 ) 3 ) 3 N + ), 3(m, 2H, (CH 3) 3 N + CH 2 ), 4.4 (m, 1H, CH(OH) 13 C-NMR(D 2 O, ppm): 43.35(CH 2 CO 2 H), 54.41(t, J=4Hz, (CH 3 ) 3 N + ), 41(CH(OH)-), 70.44((CH 3 ) 3 N + CH 2 ), 178.25(CH 2 CO 2 H) (S)-3-methanesulfonyl hydroxybutyrolactone (1.0 g, 5.6 mmol), D 2 O (10 ml), and the concentrated sulfuric acid (0.0549 g, 0.56 mmol) were placed in a 25 ml reactor and stirred at 50 C