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Furthermore, DAG generated by PNPLA2 preferentially produces 1,3- DAG which cannot activate PKC (196), suggesting that the de novo generation of DAGs leads to insulin resistance

The targeted delivery of dexamethasone to GLP1R-positive cells prevented typical dexamethasone offtarget effects on glucose metabolism, bone density, and the hypothalamus-pituitary-adrenal axis activity (164)

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While MS was initially suspected, given the history of optic neuritis and paresthesia, this diagnosis was ruled out on the basis of normal MRI findings and the absence of spinal cord involvement or demyelinating lesions