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Functional Half-Life is a Meaningful Descriptor of Steady-State Pharmacokinetics of an Extended-Release Formulation of a Rapidly Cleared Drug

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Key findings include: Upregulation of VEGFR2 expression and internalization in endothelial cells Activation of the VEGFR2-Akt-eNOS signaling cascade Enhanced endothelial cell proliferation and tube formation Improved collateral circulation in ischemic injury models The peptides pro-angiogenic effects appear particularly relevant in healing scenarios where blood supply restoration is critical for tissue recovery

[20] This effect was confirmed in a 2017 meta-analysis