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Drug-induced or chemical-induced toxicity Some clinical drugs of abuse have been demonstrated to induce organ-specific toxicity, a phenomenon that may involve the involvement of ROS

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Mice with apolipoprotein E deficiency and knocked down NF-B p50 showed higher serum levels of TNF-, IL-6, and cholesterol and more pronounced atherosclerotic lesions than mice with apolipoprotein E deficiency alone ( Upstream of NF-B has also been discussed in the IH-mediated AS

The analysis in this Appendix, in conjunction with the remainder of this document, demonstrates that this proposed rule is consistent with the regulatory philosophy and principles identified in Executive Orders 12866 and 13563, the RFA, and section 1102(b) of the Act