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Abbreviations CON: Control CNCbl10: Cyanocobalamin at 10 g/ml CNCbl40: Cyanocobalamin at 40 g/ml MeCbl10: Methylcobalamin at 10 g/ml MeCbl40: Methylcobalamin at 40 g/ml EHEC: Enterohemorrhagic Escherichia coli SURV: Survival experiment EPC: Early-stage pathogen colonization experiment PBS: Phosphate-buffered saline SAMSA2: Simple annotation of metatranscriptomes by sequence analysis 2.0 SCFA: Short-chain fatty acid INF: Interferon gamma IL: Interleukins KC: Keratinocytes-derived chemokine TNF: Tumor necrosis factor alpha GM-CSF: Granulocyte-macrophage colony-stimulating factor MMP9: Matrix metalloproteinase-9 RANTES: Regulated on activation normal T cell expressed and secreted IP10: Interferon gamma-induced protein-10 MCP1: Monocyte chemoattractant protein-1 MIP: Macrophage inflammatory proteins ASV: Amplicon sequencing variant BHI: Brain heart infusion

These dense aggregates not only serve as physical barriers but also play an active role in inflammatory clearance (121, 122)

For example, fibrin amyloid microclots blocked capillaries and impeded O2 to be transported to the tissues, leading to thrombotic events, myocardial infarction, strokes, kidney disfunction, or neurological disorders