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Andreeff M, McQueen T, Williams C, Gu J, Hopwood VL, Appleberry T, Rich C, Dallaire S, Kornblau SM , R-Y W

In this regard and under hypoxic conditions, proline gets metabolized into pyrroline-5-carboxylate (P5C) with the help of proline oxidase (POX) enzyme, which elicits ROS production that promotes protective autophagy mechanism, which is necessary for the survival of HT29 cells (127)