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Although these classes are discussed individually in the following sections, their molecular targets converge within a vertically organised regulatory hierarchy encompassing epigenetic, redox-inflammatory, and metabolic-energy regulatory layers (Figure 4)

doi: 10.1210/en.2016-1500

A Dirty Gene is Caused By: High Blood Sugar Stimulates more GDF15 production High Insulin Stimulates more GDF15 production Fat Tissue Produces more GDF15 than other tissues