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It is very difficult to make recommendations or draw valid conclusions on the effectiveness of oral supplements and systemic drugs in the treatment of skin aging, as most of the evidence is based on small, single-center studies with short follow-up periods (mostly 24 months), predominantly female samples, and use of heterogeneous methodologies and evaluation criteria

Nature 352 , 337339 (1991)

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To warm up the fluids, fill a sink or large bowl with warm water