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Here are key points about these regulations and guidelines: : Various countries have specific regulatory agencies overseeing cell-based therapies

Disease-causing variants in the primary genes associated with low pyruvate dehydrogenase complex activity result in pyruvate dehydrogenase complex deficiency by interfering with pyruvate flux and energy production from carbohydrate oxidation with resultant lactic acidemia, hyperpyruvicemia, hyperalaninemia, and hyperprolinemia aggravated with consumption of carbohydrate

J Cereb Blood Flow Metab 32:816824 Tildon JT, Roeder LM (1984) Glutamine oxidation by dissociated cells and homogenates of rat brain: kinetics and inhibitor studies