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Seralutinib in adults with pulmonary arterial hypertension (TORREY): a randomised, double-blind, placebo-controlled phase 2 trial

Three CSP biotinylated peptides, Pep1, Pep3 and Pep5 ( Figure 2D ) representing the three PepSpot C4bp binding signals ( Figure 2B ) were synthesized

Animal experiments confirmed that dural injection of bone marrow mesenchymal stem cell-derived exosomes miR-367-3p significantly reduced the expression of EZH2 in spinal cord tissues of EAE mice, increased the expression of SLC7A11, GPX4, GSH, and SOD, decreased the levels of Fe 2+ and MDA, inhibited spinal cord iron deposition, ferroptosis, and inflammation, and alleviated spinal cord injury ( 2+ and MDA levels, while reducing GSH, NRF2, and GPX4 expression, as well as iron reactive element binding protein 2 (IREB2) in optic nerve tissue

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