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Class 3 ferroptosis inducers, which include the compounds ferroptosis inducer 56 (FIN56) and caspase-independent lethal 56 (CIL56), act by depleting GPX4 protein from cells and simultaneously causing depletion of mevalonate-derived coenzyme Q 10 (CoQ 10 ), which functions as an endogenous lipophilic antioxidant in addition to its well-known function in the mitochondrial electron transport chain [13]

However, performing a patch test is recommended before regular application

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