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Keywords: chronic kidney disease, EGCG, green tea, inflammation, apoptosis Introduction Chronic kidney disease (CKD) is a longterm form of kidney disease, characterized by a progressive loss in renal function

Under conditions of chronic stress or systemic inflammation, enzymes such as indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are upregulated, diverting TRP metabolism away from 5-HT synthesis toward KYN production, with profound consequences for both peripheral physiology and central nervous system (CNS) function

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Van Dam EW, Roelfsema F, Helmerhorst FH, Frlich M, Meinders AE, Veldhuis JD, Pijl H