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Photo-oxidation is exacerbated during retinal degeneration and progressive loss of photoreceptors, as the choroid cannot alter the inflow of oxygen supply in response to the changing retinal environment, so the remaining photoreceptors become exposed to a higher oxygen level 22

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Hilund-Carlsen et al., 2024)

Erastin is a synthetic drug that induces cell death through ferroptosis in tumor cells bearing mutant RAS by increasing intracellular ROS levels and altering the permeability of the outer mitochondrial membrane 130,131