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An eGFR just below 60 typically indicates the presence of early-stage CKD and is also associated with a significantly increased risk of cardiovascular and any-cause mortality, kidney failure, acute kidney injury, or the progression of CKD

For example, clinical observations of neurological complications in 236,379 patients in the 6 months after a COVID-19 diagnosis found that 33.62% of patients had demonstrated clinically important neurological or psychiatric dysfunction 4

This underscores that selectivity remains the central challenge currently facing ferroptosis-based therapies

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