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a 40 ml bottle provides a stable, bioactive peptide solution suitable for multiple scientific studies, typically lasting several weeks when used in standard research protocols

But only a maximum of 5mcg of B12 enters the bile every day (according to "Advanced Haematology" 7th edition textbook, page 60), so it seems that only an additional 5mcg would be lost daily if none was recovered

B12 deficiencies are particularly common among vegetarians, with one German study reporting that only 5.3% of vegetarians meet the recommended intake of B12

Overgrowth of bacteria: Some people develop vitamin B 12 deficiency as a result of conditions that slow the movement of food through the intestines (diabetes, scleroderma, strictures, diverticula), allowing intestinal bacteria to multiply and overgrow in the upper part of the small intestine