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Synthesis and structureactivity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles

Recently, it was discovered that CDK5 is also a downstream effector of casein kinase 2 (CK2), which activates CDK5 to mediate white matter ischemia [30], and a possible coregulation between CDK5 and Notch signaling [31]