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The results revealed statistically significant mean differences in C-reactive protein serum levels between groups at 24 h postadjunctive therapy with melatonin and a significant improvement of clinical condition in neonates from the intervention group compared to the control group within 3 days of therapy 109

JAMA Netw Open 2022;5:e2212686 23

Yang et al., 2014), despite each isoform being encoded by different genes and showing different tissue expression patterns (Cuadrado and Nebreda, 2010)

The lack of equitable access, behavioral and cultural change, regulation of quality of commercial products and methodological fortification of the evidence base are rather numerous issues that are to be solved yet they can be addressed in collaboration of the research, policy, industry and civil society