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Since H 2 O 2 readily crosses membranes, it can act as a second messenger akin to Ca 2+

it reacts only slowly with Oxygen, is less susceptible to auto-oxidative degradation than is cysteine Soluble in the plasma GSH comes in with the diet (150 mg daily by rough estimate) Hormones and other vasoactive substances increase GSH efflux into the bile Strategies for Repleting Cellular Glutathione Oral dosing with GSH An oral bolus of 15 mg/kg to the human to raise plasma GSH two-to five-fold The intestinal lumen absorb GSH via non-energy- requiring, carrier-mediated diffusion, and later export it into the blood (lung alveolar cells, vessel endothelial cells, retinal pigmented epithelial cells, and cells of the kidney's proximal tubule

Vegetarianism, female gender and increasing age, but not CNDP1 genotype, are associated with reduced muscle carnosine levels in humans