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NAC improved both motor and non-motor symptoms and significantly increased GSH/GSSG ratios, GSH levels in the CSF, and DAT binding

Moreover, the role of bile acid receptors such as the Farnesoid X receptor (FXR) and G protein bile acid-activated receptor 1 (GPBAR1) is crucial in regulating inflammatory responses and metabolic disruptions, including lipid imbalances, across both hepatic and neural environments

FEBS J 282(11):20762088 Chan Nickie C, Salazar AM et al (2011) Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy[J]