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In experimental models, diabetes reduces NGF expression in target tissues including skin and muscle, impairing retrograde transport to neuronal cell bodies and decreasing neuropeptides such as substance P and calcitonin gene-related peptide [146]

Additionally, different subregions of the mPFC play different roles in fear expression, which may be related to differences in the distribution of GABA receptor subtypes

The intestinal enzymatic degradation which the GSH is subjected to, leads to its poor absorption and a low bioavailability and requires a very long oral GSH supplementation in order to appreciate a possible increase of its levels

In addition, as indicated by EFSA, vitamin C contributes to the normal function of the immune system