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The prescribing information for Rybelsus also says to : Take it when you first wake up, before eating or drinking anything, while you still have an empty stomach Swallow each tablet whole, using only a small sip of water (four ounces or less) Wait 30 minutes before having additional liquids, food, or other oral medications When in doubt, go with your healthcare providers instructions and reach out to them if youre ever unsure how to take your medication

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