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This observation has been interpreted by some as evidence for predominant non-oxidative glucose consumption within activated tissue (Fox et al., 1988

It is important to note that flavonoids can exhibit both antioxidant and pro-oxidant properties, and their behavior may be influenced by factors such as test conditions, effective concentration at the site of ROS formation, stability of the flavonoid radical formed during hydrogen atom donation, lipophilicity for membrane absorption, and pH of the medium