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10.1021/acs.jafc.7b02125 271

Fisetin is also a compound with senolytic properties [119]

A recent study reported that nasal administration of TiO 2 -NPs (2.510 mg/Kg/90 days) to mice caused neuronal death in the hippocampus, oxidative stress and gliosis, and microarray analysis revealed a decline of genes associated with memory and cognition (Ze et al., 2014)