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They include CAMP-response element binding protein (CREB), SP1 transcription factor (SP1), transcription factor AP-2 (AP2), proliferator-activated receptor alpha (PPAR), all activating GPX4 expression, while Krppel-like transcription factor 2 (KLF2) and CAMP-response element modulator (CREM), both repress its protein expression [7]

Pigmentation & Skin-Integrity Research Research involving Glutathione commonly investigates its interaction with: Tyrosinase-related mechanisms Melanin-related signaling pathways Oxidative-stress regulation within melanocyte research models Skin-integrity and dermal-maintenance pathways These pathways have contributed to broader research interest in Glutathione within pigmentation-related, dermatological, cosmetic, and skin-quality investigations

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