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(DOI: 10.3389/fnagi.2020.00166)

Additionally, combining PARP-1 inhibitors with immune checkpoint blockers or agents that target DNA repair may improve treatment effectiveness

Frontiers in Neurology 9:844

As with SIRS, CARS is a complex immune response involving anti-inflammatory and immunosuppressive mechanisms that are able to restore homeostasis after injury and SIRS or, if unchecked leads to a state of profound immunosuppression, predisposing the individual to infections [52, 55]