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That distinction matters for understanding why systemic IGF-1 LR3 administration and local MGF activity are not equivalent in their biological targets, even though both ultimately activate many of the same downstream signalling nodes

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Clinical trial data shows heart rate increases across most participants at therapeutic doses, but the magnitude varies significantly

It does not interact with estrogen or testosterone pathways and has no known risk of virilization or masculinizing effects, making it an ideal option for female athletes focused on recovery, body composition, or anti-aging