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Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity

The receptor exists in two splice variants: the active GHS-R1a, which binds acylated ghrelin, and the truncated GHS-R1b, which is pharmacologically inactive but can modulate the activity of 1a through heterodimerisation

In a retrospective study wherein BMI was used as a proxy for adiposity (median age 40 yr, range 2077 yr, median BMI 26 kg/m2, range 18.349.8 kg/m2), total and pulsatile 24 hour GH secretion were both negatively associated with BMI, and GH secretion was higher in women than men below 50 years of age, likely due to the influence of estradiol levels on IGF-1 levels (22) (Figures 3,4)

Treatments are administered by injection, often just before bedtime, to mimic the bodys natural GH release patterns