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Moreover, pharmacological inhibition of this cleavage delays neurodegeneration [386, 387]

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The patients studied were typical of men with severe ED and were not getting good results from oral ED medication

Intra-articular/soft-tissue injection: The dose depends on the size of the joint or lesion. A general guideline (from FDA labeling) is: Large joints (knee, ankle, shoulder) 2080 mg (0.52 mL); Medium joints (elbow, wrist) 1040 mg (0.251 mL); Small joints (fingers, toes) 410 mg (0.10.25 mL). Tendon sheath or bursa injections usually use 430 mg. For example, a knee might receive 40 mg once, while an inflamed finger joint might get 5 mg. Practitioners often aspirate synovial fluid first to confirm needle placement, then inject Depo-Medrol into the joint space. The joint is gently moved afterward to mix the steroid suspension. Repeat injections (if needed) are typically spaced by several weeks (e.g. 46 weeks) to monitor response and avoid excess steroid exposure