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Jiyah A, Muhammad SA, Ibrahim A, Bulama I, Ibrahim A, Abbas AY, et al

Cell 184 , 12991313.e1219 (2021)

Stromal interaction molecule 1 (STIM1) detects ER calcium depletion, translocates to ER-plasma membrane junctions, and activates Ca 2+ release-activated channels (CRAC) by tethering Orai proteins, triggering CaMKK activation, which phosphorylates AMPK at Thr172

TASK-3 channels are widely distributed in several brain regions, such as the hippocampus, cortex, and cerebellum, as well as in specific nuclei, including the locus coeruleus, paraventricular nucleus of the thalamus, and dorsal raphe nucleus (Talley et al., 2001)