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The repertoire of natural IgA is restricted and affinity maturation is limited, although the heavy-chain variable region genes used by IgA-producing plasma cells in the gut are somatically hyper-mutated, to diversify antibody specificity [42]

Neurotrophin therapy improves recovery of the neuromuscular continence mechanism following simulated birth injury in rats

Several stressors exert a brain CRF 1 -mediated stimulatory action on colonic motor functions in rodents (Tach and Million, 2015)

Vitamin C Vitamin C, or ascorbic acid, is a water-soluble nutrient vital for proper immune function that cannot be synthesized endogenously