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Clinical treatment strategy for MTHFR-related psychiatric disorders As MTHFR plays a critical role in one-carbon metabolism, which is composed of folate, homocysteine, vitamin B12, and methylation of DNA, mutation of specific gene locus on MTHFR and correlative enzyme activity decline will affect various of physiological events as well as some pathology states, including psychiatric disorders

Regular monitoring is therefore essential for at-risk populations, even when dietary intake appears adequate

However, it cannot be legally imported without a special permit under the strict Special Access Scheme, which requires a doctor to apply to the TGA for permission to treat a particular patient with the drug, including describing the specific clinical need

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