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Actomyosin contractility can compromise nuclear integrity by squeezing the nucleus dorsoventrally [191, 192], pulling it [193] or promoting the nuclear influx of cytoplasmic constituents, which in turn pressurizes the nucleus, leading to its rupture [155]

It also crosses the blood-brain barrier, which has some researchers interested in its potential effects on nerve tissue and spinal injuries

The dermal matrix loses organized, crosslinked collagen over time, while the enzymes that break collagen down can become relatively more active

However, the longevity community has taken sharp notice of them because obesity and metabolic dysfunction are among the most potent accelerants of biological aging