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PINK1, as a mitochondrial damage sensor, is activated by mild oxidative stress and further triggers mitophagy to remove ROS and prevent cellular damage [167]

Here, we critically evaluate and discuss advances in development of currently reported transporter-utilizing (pro)drugs and nanocarriers in light of the main CNS pharmacokinetic principles

To induce acute peripheral sympathectomy, 6-OHDA powder (Sigma-Aldrich, 162957) was dissolved in sterile saline containing 1% ascorbic acid (Sigma-Aldrich, A4544) as an anti-oxidant and kept on ice and covered with foil before injection

This limitation underscores the need for broader and more in-depth investigations into the relationships between environmental pollutants and urolithiasis in future work