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The third (ChaC1-juglone-C2-glutathione-adduct) and fourth (ChaC1-juglone-C3-glutathione-adduct) model systems were generated by docking two types of juglone-glutathione adducts at the glutathione binding site of ChaC1

Nanaomycin A ( 64 ) is an antibiotic that was recently reported to selectively inhibit DNMT3B with an IC 50 of 500 nM, while the activity of DNMT1 was not affected (Figure 10)

We defined the 'global target' as the outlier-corrected mean of the two best-performing global assays (HPLC-MS and Pyroseq NBL2), and we tested several approaches for predicting the sample-specific global target values from the locus-specific data

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