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LAMPs were originally believed just to be structural proteins that protect lysosomal membrane from resident hydrolytic enzymes, although evidence now reveals that they have a key physiological role in suppressing proton leak through TMEM175 channels to facilitate re-acidification when lysosomal pH rises inappropriately 96

Liver ischemia-reperfusion injury (IRI) Liver IRI occurs due to the cessation and restoration of blood supply, which severe liver injury [111]

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