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Memory dysfunction is frequently comorbid with age-related neurodegenerative diseases, such as Alzheimer's disease (AD) ( Memory dysfunction seriously impacts performance of routine tasks necessary for a productive and healthy life, including the ability to maintain gainful employment and compliance with treatment plans ( Synthesis, Structure, Transport and Cellular Targets of Neurosteroids Synthesis and Translocation Neurosteroid synthesis involves translocation of cholesterol across the mitochondrial membrane by transport proteins, such as the steroidogenic acute regulatory protein (StAR protein), the translocator protein (TSPO), voltage-dependent anion channel (VDAC) protein and the adenine nucleotide transporter (ANT) protein (93)

Importantly, drugs targeting -synuclein could be trapped in endothelial cells where the protein accumulates

When researchers looked at all participants regardless of whether they stuck with the medication, the numbers were similar: 11.5% versus 3%