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Moreover, considering the seno-antigens typically have important roles in intracellular signaling and regulation of immune responses, it remains to be investigated whether the inhibition of uPAR expressing cells could result in side effects such as impaired immune response, and their long-term effect on health status and lifespan remains poorly understood

The ectonucleotidase CD39 identifies tumor-reactive CD8 + T cells predictive of immune checkpoint blockade efficacy in human lung cancer